Vitamin K2 Menaquinone Mk7

CAS Number: 2124-57-4

Molecular Formula: C46H64O2

Formula Weight: 649.0

Purity: 1500ppm; 2000ppm; 10000ppm; 13000ppm; 20000ppm; 50000ppm

Carrier: Olive oil, MCT oil (medium-chain triglycerides), sunflower oil

Fermentation: Bacillus subtilis natto

Standards: Complies with USP 40 Monographs and USP 43 Monographs

Vitamin K2-7, which is also called menaquinone-7 (MK-7), provides health benefits in various conditions such as osteoporosis, cardiovascular disease, inflammation, cancer, Alzheimer's disease, diabetes, and peripheral neuropathy. Vitamin k2 Menaquinone mk7 is more easily absorbed and has higher bioavailability than vitamin K1 (phylloquinone). Clinical studies have clearly shown that Vitamin k2 Menaquinone mk7 supplementation can improve peripheral neuropathy, reduce the risk of bone fractures, and enhance cardiovascular health.

For instance, Vitamin K2 MK7 is known to play a critical role in maintaining bone health and density. It works by activating osteocalcin, a protein that is essential for bone formation.

Osteocalcin requires vitamin K2 MK7 to bind to calcium and incorporate it into the bone matrix. Without sufficient levels of vitamin K2 MK7, osteocalcin cannot function properly, and calcium may be deposited in soft tissues instead of bones, leading to bone loss.

Research has shown that vitamin K2 MK7 supplementation can improve bone mineral density in postmenopausal women and elderly individuals. In a study, postmenopausal women who took vitamin K2 MK7 supplements for three years had a significant increase in bone mineral density compared to those who did not take the supplements.

Furthermore, Vitamin K2 MK7 has been found to reduce the risk of fractures in older adults. A clinical trial conducted on 244 postmenopausal women found that those who received a daily supplement of vitamin K2 MK7 had a significantly lower risk of vertebral fractures compared to those who did not take the supplement.

The basic flow chart for the production of Vitamin K2 MK7 by fermentation:

Cultivation of Bacillus subtilis: The first step in the production of Vitamin K2 MK7 by fermentation is to cultivate Bacillus subtilis bacteria. This can be done in a bioreactor using a suitable growth medium.

Fermentation: Once the Bacillus subtilis culture is established, it is then fermented in the bioreactor. The fermentation process can take several days or weeks, during which time the bacteria produce Vitamin K2 MK7.

Harvesting: Once the fermentation process is complete, the culture broth is harvested from the bioreactor. The culture broth contains the Vitamin K2 MK7 produced by the bacteria.

Separation and purification: The culture broth is then subjected to a series of separation and purification steps to isolate the Vitamin K2 MK7. This can include filtration, centrifugation, and chromatography.

Drying: The purified Vitamin K2 MK7 is then dried to remove any remaining moisture and prepare it for further processing or packaging.

Quality control: The final product is subjected to quality control testing to ensure that it meets the required specifications for purity, potency, and safety.

Packaging: The final step is to package the Vitamin K2 MK7 in suitable containers for distribution and use.

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